Document Type : Research Paper
Student Research Committee, School of Medicine, Shahroud University of Medical Sciences, Shahroud, Iran
Clinical Research Development Unit, Imam Hossein Hospital, Shahroud University of Medical Sciences, Shahroud, Iran
Student Research Committee, School of Medicine, Shahid Beheshti University of Medical Sciences,
Department of Epidemiology, School of Public Health, Shahroud University of Medical Sciences, Shahroud, Iran
Background and objective: People with asthma are generally more susceptible to respiratory infections than the general population. As a result, patients with asthma are presumed to be at a higher risk of COVID-19 and health complications during the current pandemic. However, the relationship between asthma and COVID-19 remains unclear.
Method:This cross-sectional study was done in Imam Hossein hospital of Shahroud. Considering the prevalence of 4.7% of asthma in Iran , the confidence interval of 95% and the power of 80%, 93 patients were entered in the study.. Based on pre-existing asthma, the study population was divided into two groups; the COVID-19 patients with asthma and the COVID-19 patients without asthma. Lastly, the study compared the groups in terms of clinical course and laboratory findings. Patients with a history of smoking, diabetes, cardiovascular disease, COPD, and hypertension were excluded from the study.
Results: Among 93 COVID-19 patients, mean lymphocyte count (mean±SD=2.1±1.1, p-value=0.001) and serum glutamic oxaloacetic transaminase (SGOT) level (mean±SD=34.3±19.5, p-value=0.001) were higher in the patients without asthma. By contrast, asthma patients had a higher prevalence of heart rate disorders (27%, p value=0.04 ), positive C-reactive protein (CRP) results (40%, p value=0.0001). Also, a significantly higher frequency of high diastolic blood pressure (DBP) was present in the asthma group (p-value= 0.02). Other variables did not show any significant association.
Conclusion: Patients with mild to moderate asthma were not significantly different from non-asthmatic patients in terms of severity of the disease.