What is the Probability of a Live Birth after a New IVF/ICSI -ET in Patients with History of Unexplained Recurrent Implantation Failure?

Document Type : Research Paper


Reproductive Biotechnology Research Centre, Avicenna Research Institute, ACECR, Tehran, Iran, & Avicenna Infertility Clinic, Avicenna Research Institute, ACER, Tehran, Iran


Background and Objective: The main objective of this study was to determine pregnancy & live birth rates after a new IVF/ICSI and fresh embryo transfer in patients with history of unexplained recurrent implantation failure (RIF).
Method: In this prospective cohort study, 50 unexplained RIF patients who were scheduled for a new IVF/ICSI –ET treatment in Avicenna specialized and tertiary center for infertility treatment, were followed to determine pregnancy & live birth rates. All patients were assessed for inclusion and exclusion criteria also had informed consent before entering the study.
Results: The mean age of patients was 33.57±4.63 years. Mean number of previous unsuccessful IVF/ICSI -ET cycles was2.72±1. The average number of oocytes picked up via ovarian puncture was 11.2±6.5   and mean number of grown embryos was 5±6. Four of 50 patients were excluded from the study,10 of 46(21.7%) patients had positive pregnancy tests, clinical pregnancy also live birth rates per ICSI cycle was   8/46 (17.3%). one case of ectopic pregnancy, one chemical and two clinical pregnancy losses also two twin pregnancies, one of them resulted in preterm labor in 34th week, happened. Sides effects such as infection, hemorrhage and fetal anomaly didn't occur in patients.
Conclusion:  This study showed that pregnancy and live birth   rates per new ICSI- ET cycle for unexplained RIF patients   were21.7% and 17.3% respectively. These rates are less than success rates among the general population scheduled for IVF/ICSI -ET with no history of unexplained recurrent implantation failure. Therefore, unexplained RIF patients may need to undergo a greater number of ART cycles to gain a live birth.