What is the Probability of a Live Birth after a New IVF/ICSI -ET in Patients with History of Unexplained Recurrent Implantation Failure?

Background and Objective: The main objective of this study was to determine pregnancy & live birth rates after a new IVF/ICSI and fresh embryo transfer in patients with history of unexplained recurrent implantation failure (RIF).
Method: In this prospective cohort study, 50 unexplained RIF patients who were scheduled for a new IVF/ICSI –ET treatment in Avicenna specialized and tertiary center for infertility treatment, were followed to determine pregnancy & live birth rates. All patients were assessed for inclusion and exclusion criteria also had informed consent before entering the study.
Results: The mean age of patients was 33.57±4.63 years. Mean number of previous unsuccessful IVF/ICSI -ET cycles was2.72±1. The average number of oocytes picked up via ovarian puncture was 11.2±6.5   and mean number of grown embryos was 5±6. Four of 50 patients were excluded from the study,10 of 46(21.7%) patients had positive pregnancy tests, clinical pregnancy also live birth rates per ICSI cycle was   8/46 (17.3%). one case of ectopic pregnancy, one chemical and two clinical pregnancy losses also two twin pregnancies, one of them resulted in preterm labor in 34^th week, happened. Sides effects such as infection, hemorrhage and fetal anomaly didn't occur in patients.
Conclusion:  This study showed that pregnancy and live birth   rates per new ICSI- ET cycle for unexplained RIF patients   were21.7% and 17.3% respectively. These rates are less than success rates among the general population scheduled for IVF/ICSI -ET with no history of unexplained recurrent implantation failure. Therefore, unexplained RIF patients may need to undergo a greater number of ART cycles to gain a live birth.